
SPM Active® by Metagenics® – Pro-Resolving Mediators for Immune & Inflammatory Response | 60 or 120 Softgels
SPM Active® by Metagenics® – Pro-Resolving Mediators for Immune & Inflammatory Response | 60 or 120 Softgels
KEY BENEFITS
• Targeted Inflammation Resolution Support
• Helps promote resolution of minor pain and physical discomfort
• Supports tissue health after exertion
• Clinically shown to improve joint comfort, sleep, and mood*
• Provides specialized pro-resolving mediators (SPMs) the body may not produce sufficiently
WHAT IT IS / WHAT IT DOES
SPM Active® delivers specialized pro-resolving mediators (SPMs)—molecules naturally produced by the body to support the resolution phase after physical stress, exertion, and tissue strain.
Lifestyle, diet, and inflammation can reduce the body’s ability to produce these mediators, leaving the immune response incomplete. SPM Active® helps supplement this natural process.
Human clinical data has shown that SPM supplementation supports joint comfort, tissue health, sleep quality, and overall physical recovery.*
FEATURES
• The only SPM supplement with human clinical data showing measurable results*
• Helps promote healthy tissue recovery
• Shown in clinical research to improve joint comfort, sleep, and mood*
• Supports individuals experiencing everyday physical discomfort
• Provides SPMs derived from high-quality fish oil (EPA & DHA)
• Available in 2 Versions: Original Formula & Improved Fromula
INGREDIENTS
Medicinal Ingredient (per softgel):
• Fish Oil – 500 mg
• Providing 50 mg EPA and 100 mg DHA
• Sourced from sardine, anchovy, and mackerel
Non-Medicinal Ingredients:
• Mixed tocopherols concentrate
• Softgel (gelatin, glycerin, water)
• Silica
RECOMMENDED DOSE
• Adults & Adolescents (12–17): Take 2 softgels once daily or as directed by your healthcare practitioner.
• Supports cardiovascular health, cognitive health, and overall wellness.

CAUTIONS / WARNINGS
• Keep tightly closed in a cool, dry place.
• Do not use if the perma seal is missing.
• Consult your healthcare practitioner if pregnant, breastfeeding, or taking medication.
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SPM Active® by Metagenics® – Pro-Resolving Mediators for Immune & Inflammatory Response | 60 or 120 Softgels
KEY BENEFITS
• Targeted Inflammation Resolution Support
• Helps promote resolution of minor pain and physical discomfort
• Supports tissue health after exertion
• Clinically shown to improve joint comfort, sleep, and mood*
• Provides specialized pro-resolving mediators (SPMs) the body may not produce sufficiently
WHAT IT IS / WHAT IT DOES
SPM Active® delivers specialized pro-resolving mediators (SPMs)—molecules naturally produced by the body to support the resolution phase after physical stress, exertion, and tissue strain.
Lifestyle, diet, and inflammation can reduce the body’s ability to produce these mediators, leaving the immune response incomplete. SPM Active® helps supplement this natural process.
Human clinical data has shown that SPM supplementation supports joint comfort, tissue health, sleep quality, and overall physical recovery.*
FEATURES
• The only SPM supplement with human clinical data showing measurable results*
• Helps promote healthy tissue recovery
• Shown in clinical research to improve joint comfort, sleep, and mood*
• Supports individuals experiencing everyday physical discomfort
• Provides SPMs derived from high-quality fish oil (EPA & DHA)
• Available in 2 Versions: Original Formula & Improved Fromula
INGREDIENTS
Medicinal Ingredient (per softgel):
• Fish Oil – 500 mg
• Providing 50 mg EPA and 100 mg DHA
• Sourced from sardine, anchovy, and mackerel
Non-Medicinal Ingredients:
• Mixed tocopherols concentrate
• Softgel (gelatin, glycerin, water)
• Silica
RECOMMENDED DOSE
• Adults & Adolescents (12–17): Take 2 softgels once daily or as directed by your healthcare practitioner.
• Supports cardiovascular health, cognitive health, and overall wellness.

CAUTIONS / WARNINGS
• Keep tightly closed in a cool, dry place.
• Do not use if the perma seal is missing.
• Consult your healthcare practitioner if pregnant, breastfeeding, or taking medication.
Product Information
Product Information
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Description
KEY BENEFITS
• Targeted Inflammation Resolution Support
• Helps promote resolution of minor pain and physical discomfort
• Supports tissue health after exertion
• Clinically shown to improve joint comfort, sleep, and mood*
• Provides specialized pro-resolving mediators (SPMs) the body may not produce sufficiently
WHAT IT IS / WHAT IT DOES
SPM Active® delivers specialized pro-resolving mediators (SPMs)—molecules naturally produced by the body to support the resolution phase after physical stress, exertion, and tissue strain.
Lifestyle, diet, and inflammation can reduce the body’s ability to produce these mediators, leaving the immune response incomplete. SPM Active® helps supplement this natural process.
Human clinical data has shown that SPM supplementation supports joint comfort, tissue health, sleep quality, and overall physical recovery.*
FEATURES
• The only SPM supplement with human clinical data showing measurable results*
• Helps promote healthy tissue recovery
• Shown in clinical research to improve joint comfort, sleep, and mood*
• Supports individuals experiencing everyday physical discomfort
• Provides SPMs derived from high-quality fish oil (EPA & DHA)
• Available in 2 Versions: Original Formula & Improved Fromula
INGREDIENTS
Medicinal Ingredient (per softgel):
• Fish Oil – 500 mg
• Providing 50 mg EPA and 100 mg DHA
• Sourced from sardine, anchovy, and mackerel
Non-Medicinal Ingredients:
• Mixed tocopherols concentrate
• Softgel (gelatin, glycerin, water)
• Silica
RECOMMENDED DOSE
• Adults & Adolescents (12–17): Take 2 softgels once daily or as directed by your healthcare practitioner.
• Supports cardiovascular health, cognitive health, and overall wellness.

CAUTIONS / WARNINGS
• Keep tightly closed in a cool, dry place.
• Do not use if the perma seal is missing.
• Consult your healthcare practitioner if pregnant, breastfeeding, or taking medication.























